SL21s

 

THE CELLULAR PHYSIOLOGY
There is a clear reason for the success of PurePRP®. The cellular physiology of PurePRP® is ideal. Based in the independent data evaluation of the cellular composition and structure of PurePRP® we are able to see the following key points.


Deliverable Platelets
Deliverable platelets are the actual volume of viable platelets contained in a PRP sample. PurePRP® provide upwards of 9.5 billion platelets in a 7mL PurePRP® sample (significantly higher than its closest competitor). High volumes of deliverable platelets enhances the volumetric activity of platelet growth factors and cytokines. Platelet alpha granules contain various platelet growth factors that can promote tissue repair along with platelet cytokines that can provide the chemical stimulus needed to attract and direct regenerative cells to injured tissue. Deliverable platelets are significant in low application volumes.

Neutrophils and Monocytes
Neutrophils are the most abundant leukocyte and one of the first-responders to migrate towards a site of injury or infection (chemotaxis). Neutrophils are also the hallmark of acute inflammation. This is an aggressive response of chemical signals from cytokines such as interleukins (IL-1, IL-8) and tumour necrosis factor alpha (TNF-α) along with many others. The primary function of the neutrophil is to engulf and destroy foreign material through phagocytosis. Under normal circumstances, neutrophils are short lived (1-2 days) and are cleared by tissue macrophages. In conditions where the neutrophils cannot be cleared, for a lack of macrophages, they undergo a process called necrosis resulting in the release of all of the intracellular contents. This causes the amplification and prolonging of the inflammatory response. This prolonged amplified inflammatory response potential, is a concern.

Monocytes are the largest of all leukocytes and are characteristically non-inflammatory phagocytic cells. Monocytes migrate to sites of injury and infection and differentiate into macrophages and dendritic cells to elicit an immune response which last for longer periods of time (months rather than days when compared to neutrophils). Monocytes illicit the immune response through phagocytosis, antigen presentation, and cytokine production each of which has a specific and deliberate function in enhancing the immune response through both protective prophylaxis and active phagocytosis.

PurePRP® is unique in that it greatly enhances monocyte concentrations, while giving the end user control over the amount of neutrophils they would like to add to their PRP preparation. PurePRP® takes advantage of the long term phagocytic and protective properties of the monocytes while avoiding the potential harmful inflammation incurred by large concentrations of neutrophils that go through cellular necrosis. Another differentiating factor that help to explain the natural success of PurePRP®.