Clinical Platelet Rich Plasma (C-PRP)

and PurePRP® SupraPhysiologic

Nature's Regenerative Powerhouse



About Platelet Rich Plasma

Platelet rich plasma is a complex composition of cellular components that, when prepared properly, can be used to heal and repair a host of injuries and conditions.  Platelet rich plasma is a biologic, and the cornerstone of the consortium of regenerative therapies used in modern medicine. It is chosen over surgery for many conditions, ranging from degenerative joint disease, to tendon and ligament tears.  When it is prepared correctly, it can make a difference in your recovery.


What is Clinical Platelet Rich Plasma (C-PRP)

Clinical platelet rich plasma (C-PRP) contains a clinical dose of concentrated platelets in a treatment sample. Scientific studies provide proof of bone and soft tissue healing enhancement with a minimum PRP platelet count of 1,000,000 platelets per microliter1.  This translates to a minimum of 1 billion platelets per milliliter.  Therefore, a 5mL treatment sample of C-PRP should contain at least 5 billion deliverable platelets, for clinical efficacy. 


Importance of Platelets in C-PRP

Platelets contain alpha granules that are full of growth factors.  These growth factors are key to the proliferative repair of damaged tissue. Growth factors stimulate cellular growth, differentiation, proliferation and healing. Growth factors are the single most important component of C-PRP when used as a regenerative biologic.  Growth factors in C-PRP are a potent and effective releasate.


Other Important Cells in C-PRP

Other cells that are just as important as platelets in C-PRP are white blood cell mediators, cytokines and hormones.  These include agranular cell types such as lymphocytes, monocytes, and macrophages.   These cells provide a powerful antimicrobial effect.  They bolster the local immune response through the uptake of microbes and particles followed by its digestion and destruction.  They also act as signaling molecules between cells. They bind to specific receptors on the surface of their target cells and attract regenerative cells to it.  These cells are a paramount component of C-PRP and add to its clinical power and potency.


What C-PRP Should Not Have

C-PRP has less than 1% of red blood cells.  Whole blood hematocrit levels should not exist in C-PRP.  Studies show that short intra-articular bleeding in-vivo or a short exposure of cartilage to blood in-vitro induces lasting degenerative changes in cartilage independent of synovial inflammation2.  Studies also show that synovial fluid treated with red blood cells resulted in significant cell death and pro-inflammatory mediator production.  Red blood cells is a deleterious byproduct of C-PRP.


Why Choose

PurePRP® SupraPhysiologic

  Autologous healing that's redefining how we care for our patients



 Clear Success of PurePRP® SupraPhysiologic

There is a clear reason for the success of PurePRP® SupraPhysiologic. It has the perfect cellular composition at ideal concentrations.  It is a clinical marvel that's not duplicated anywhere.  PurePRP® SupraPhysiologic provides the most powerful concentration of deliverable regenerative cells, without the deleterious contaminants found in most PRP products.  The system is a result of 20 years of bio-engineering research, strictly focused on isolating and harvesting the most powerful regenerative components of your blood and bone marrow, while leaving the unwanted substances behind.  This carefully orchestrated and painstaking task has yielded the PurePRP® SupraPhysiologic Concentrating System.  It is the clear leader in PRP and bone marrow concentrating systems.


Deliverable Platelets Cells

Deliverable platelets are the actual volume of viable platelets contained in a PRP sample.  PurePRP® SupraPhysiologic provide upwards of 9 billion platelets in a 7mL sample of PurePRP®.  This is up to 2 billion higher than the minimum required treatment amount.  High volumes of deliverable platelets enhances the volumetric activity of platelet growth factors and cytokines.  Platelet alpha granules contain various platelet growth factors that can promote tissue repair along with platelet cytokines that can provide the chemical stimulus needed to attract and direct regenerative cells to injured tissue.  Deliverable platelets are significant in low application volumes.


Most Precise Control of Neutrophils

Neutrophils are the most abundant leukocyte and one of the first-responders to migrate towards a site of injury or infection (chemotaxis). Neutrophils are also the hallmark of acute inflammation. This is an aggressive response of chemical signals from cytokines such as interleukins (IL-1, IL-8) and tumour necrosis factor alpha (TNF-α) along with many others. The primary function of the neutrophil is to engulf and destroy foreign material through phagocytosis. Under normal circumstances, neutrophils are short lived (1-2 days) and are cleared by tissue macrophages. In conditions where the neutrophils cannot be cleared, they undergo a process called necrosis resulting in the release of all of the intracellular contents. This causes the amplification and prolonging of the inflammatory response. This prolonged amplified inflammatory response potential raises concern for many practitioners.


Non Inflammatory Antimicrobial Power of Monocytes

Monocytes are the largest of all leukocytes and are characteristically non-inflammatory phagocytic cells. Monocytes migrate to sites of injury and infection and differentiate into macrophages and dendritic cells to elicit an immune response which last for longer periods of time (months rather than days when compared to neutrophils). Monocytes illicit the immune response through phagocytosis, antigen presentation, and cytokine production each of which has a specific and deliberate function in enhancing the immune response through both protective prophylaxis and active phagocytosis.  PurePRP® SupraPhysiologic is unique in that it greatly enhances monocyte concentrations, while giving the end user control over the amount of neutrophils they would like to add to their PRP preparation. It takes advantage of the long term phagocytic and protective properties of the monocytes while avoiding the potential harmful inflammation incurred by large concentrations of neutrophils that go through cellular necrosis. Another differentiating factor that help to explain the natural success of PurePRP® SupraPhysiologic.


Ease of Use

Innovation has made the impossible, the indispensable, permitting the most advanced platelet rich plasma concentrating system to be even more powerful, efficient and user friendly.  PurePRP® SupraPhysiologic now stands alone, processing the most advanced C-PRP formulation in a single concentrating device. Unique self-sealing valve port and chamber sealing aspirating disc prevents exposure to ambient air.  Reduced processing time and steps lessens manipulation,  improves sterility handling and allow clinicians to more efficiently care for their patientsCounterbalancing is now simple and fast and centrifugation is a push of a button.  A sophisticated design with ground breaking innovations make the already best Concentrating System even better.


Protocol Versatility

PurePRP® SupraPhysiologic has protocol versatility. Protocol versatility is necessary to meet clinical demand. Clinicians must be able to deliver more specified PRP compositions without compromising its quality in order to meet specific clinical demands. PurePRP® SupraPhysiologic stands up to this requirement with powerful protocols.

Neutrophil Poor Protocol

Process clinical PRP without red blood cells or neutrophil granulocyte.  This protocol provides the only point of care non-inflammatory clinical PRP.  This protocol also provides the benefits of low viscosity, providing for better tissue disbursement.  This protocol is widely prefered for joint application therapies.


Neutrophil Rich Protocol

Process clinical PRP without red blood cells and enriched neutrophil concentrations.  This protocol is used when the phagocytic power of neutrophil granulocytes are needed. This protocol produces the highest level of leukocyte chemotaxis, producing temporary inflammation, for antimicrobial phagocytosis and tissue regeneration. Once the neutrophil granulocytes have completed phagocytosis, they become apoptic cells and are subsequently removed, thereby also eliminating the inflammatory activity.


NO-BURN Protocol

PurePRP® SupraPhysiologic is exceptionally unique in that it can be prepared within a special autologous scope that that allows the acidity to be completely removed without buffers or calcium activators, leaving you with clinical PRP that is perfectly tolerated by patients.



  1. Robert E. Marx, DDS. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? IMPLANT DENTISTRY. 2001;Vol. 10, No. 4: 225-228
  2. Michel Hooiveld,* Goris Roosendaal,†Marion Wenting,* Marijke van den Berg,†Johannes Bijlsma,* and Floris Lafeber*. Short-Term Exposure of Cartilage to Blood Results in Chondrocyte Apoptosis. American Journal of Pathology; Vol. 162, No. 3: 943-951
  3. Hillary J. Braun, Hyeon Joo Kim, Constance R. Chu and Jason L. Dragoo. The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes: Implications for Intra-articular Injury and Therapy. The American Journal of Sports Medicine. 2014:Vol. 42, No. 5: 1204-10



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